Endocrine Abstracts

Caffeine crosses the placenta and mammary barrier and can affect the offspring metabolism and endocrine system from heavy caffeine users. Here, we tested the impact of a safe dose of maternal caffeine (200-300 mg/day) on plasma hormone of offspring from both sexes at different ages (weaning, puberty and adulthood). For this, pregnant Wistar rats received caffeine (25mg/kg/day) by gavage or vehicle during gestation (GEST group), lactation (LACT group) or both periods (G+L group...

Neuromedin B (NB) is a peptide highly expressed in adipose tissue (AT) but its function remains unclear. We showed that NB receptor (NB) knockout mice (NBR-KO) are resistant to diet-induced obesity compared to wild type (WT) and now we aimed to analyze NBR influence in adipocytes. Mesenchimal cells from perigonadal AT of WT and NBR-KO mice were isolated and maintained in growth medium (GM) as control group or in differentiation medium (DM) as induced group. After 2 weeks cells...